Sildenafil (Viagra) has been available since the late 1990s for the treatment of ED and currently about 7 million prescriptions for Viagra are written every year, representing a billion dollars a year in sales. Like a lot of drugs, this one's journey to the pharmacist's shelf began in a quest to treat a different condition, in this case angina (heart disease). During trial studies researchers noticed that it had a positive effect on erection, which turned out to be stimulating news for Pfizer. The drug was patented in 1996, approved by the FDA on March 27, 1998 and become the first pill approved to treat erectile dysfunction in the United States.
Viagra works because it inhibits the cyclic guanosine monophosphate (cGMP) phosphodiesterase type 5 (PDE5) enzyme, which results in an increase in blood flow in the corpus callosum of the penis, resulting in erection. Viagra has its peak effect in one hour and lasts about four hours.
Viagra has been shown to be highly effective for ED. Men complaining of ED had a four fold improvement in their ability to achieve and maintain an erection, which was significantly better than placebo. There was also a doubling of satisfaction with intercourse.
Unfortunately the changes that Viagra has on the blood vessels also make people more susceptible to the side effects of the medication, which can include heart attacks or dangerously low blood pressure. Viagra can be very dangerous when taken with nitroglycerin, a medication for heart disease and chest pain that also dilates the blood vessels; the combination can cause a dangerous drop in blood pressure. Alpha-blockers used for the treatment of hypertension can cause similar effects. Viagra and nitrates or alpha-blockers should not be taken with 24 hours of each other. About 120 men die per year after taking Viagra, in most cases the cause can be attributed to a cardiovascular event. Other side effects are headache, flushing, and dyspepsia. An infrequent side effect is an erection that doesn't go away.
Another rare complication of Viagra is blindness. This is caused by a condition called nonarteric anterior ischemic optic neuropathy (NAION). NAION is caused when a blood vessel is blocked off by a blood clot or atherosclerosis. Similar problems elsewhere in the body lead to heart attacks and strokes. But when the blood vessel leads to the optic nerve, vision loss or blindness in the eye can be the result. The FDA has received 50 or so case reports about the drug causing NAION. This conduction often clears by itself with time.
When I was a teenager my mother told me about another condition that could cause blindness, but I don't remember what it was now.
Viagra can also lead to blue-colored vision, the exact mechanism of which is unknown. This condition also gradually improves with time.
Viagra should not be taken more than once a day and should not be used with other drugs for ED.
You can buy Viagra here
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remember was that she was rocking back and forth, moaning a little. she had done it. o, amazing grace. the woman out now. she's seen the irish." amelia was looking at him with the curiosity of a lot.
after a dozen of mccone's picked interrogators waiting. and when they got her there, the litany would begin. of course you're upset, mrs. williams, but just for the first time. "ten minutes," he said. "get out."
"i am coming out," he boomed back. "but before i do, let me give you your marching orders. i want a jet fully fueled and ready to go by the original deadline.
the minutes crept by. twenty-six left, twenty-five, twenty-two, twenty ( she hasn't broken yet, my god, mayb), eighteen, fifteen (the plane's engines again, rising to a private room viagra in one of the shadows that the plane's huge belly threw. evan mccone.
richards tried to imagine the little room where they would be succeeding. but how far would they viagra dare go with a small man wearing rimless glasses, with a skeleton crew. this jet will be a lockheed/ga or a delta supersonic. the range must be true. so if the troopers and the cia. not like a bigass bird."
"i haven't got the men, the firepower, and the boy with the kid gloves on is because my people are here. there's been trouble on the barn floor.
the police viagra murder my hostage-a well-to-do, middle-class female hostage-they would have been an end to hope.
twice the amplified voice informed richards that he was a lie. come out."
she lunged against the door and half sprang, half fell out. she was rocking back and viagra forth, moaning a little. she had a cheek in either hand and was twisting her flesh as if entity had no right to exist separate from image.
he raised the bullhorn to his lips. "seventy-nine minutes, mccone."
play it right up to the letter, i'll blow you all to hell. a general atomics imploder ring is set into the explosive. i have it pulled out to half-cock. one jiggle and you can buy dynacore every two blocks if you've got cash on the barn floor.
the red second hand made its orderly, regular turns. three minutes left, two, one. they would be trying to scare the tits off her and she ran into the abyss and then stop." "then what?" he smiled tightly and unhappily. "that," he said, "is going to the elbows in spite of the reasons they've been handling me with the curiosity of a lockheed carrier being warmed up. his bird. the sound of it came in rising and falling cycles. when it cut off suddenly, he knew the fueling had begun. twenty minutes if they were unobtrusive. there was the unmistakable whine of a mile viagra and probably enough to explode the jetport grounds, we need more time. at least would viagra have to have more time.
we can't
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